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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > PHCCCCAS：179068-02-1
Molecular Formula：C17H14N2O3
Molecular Weight：294.3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 179068-02-1 |
| Name | PHCCC |
| Molecular Formula | C17H14N2O3 |
| Molecular Weight | 294.3 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00947860 |
| SMILES | CCC(C)C(C(=O)NC1CSSCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CN(C(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)C(C)C)CC2=CN(C3=CC=CC=C32)C)CCC(=O)N)CC(=O)O)CC4=CNC5=CC=CC=C54)C)C)CC6=CN=CN6)CCCNC(=N)N)C(=O)N(C)C(C(C)CC)C(=O)N)NC(=O)C(CC7=CC=C(C=C7)O)N.C(=O)(C(F)(F)F)O |
| InChIKey | GDSMXERXVAAZHM-GQPSZVCTSA-N |
| InChI | InChI=1S/C83H117N23O18S2.C2HF3O2/c1-11-43(5)68(103-72(114)53(84)30-46-23-25-50(107)26-24-46)80(122)100-61-39-125-126-40-62(82(124)106(10)69(70(86)112)44(6)12-2)101-73(115)55(21-17-29-90-83(87)88)94-76(118)58(33-49-36-89-41-92-49)96-71(113)45(7)93-65(109)38-105(9)81(123)60(31-47-35-91-54-20-15-13-18-51(47)54)99-77(119)59(34-66(110)111)97-74(116)56(27-28-64(85)108)95-75(117)57(98-79(121)67(42(3)4)102-78(61)120)32-48-37-104(8)63-22-16-14-19-52(48)63;3-2(4，5)1(6)7/h13-16，18-20，22-26，35-37，41-45，53，55-62，67-69，91，107H，11-12，17，21，27-34，38-40，84H2，1-10H3，(H2，85，108)(H2，86，112)(H，89，92)(H，93，109)(H，94，118)(H，95，117)(H，96，113)(H，97，116)(H，98，121)(H，99，119)(H，100，122)(H，101，115)(H，102，120)(H，103，114)(H，110，111)(H4，87，88，90);(H，6，7)/t43?，44-，45-，53+，55-，56?，57?，58-，59-，60?，61-，62?，67?，68-，69-;/m0./s1 |
| PubChem CID | 168013663 |
| Target Point | mGluR |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | It is a type I mGluR (Group I mGluR) antagonist and a positive regulator of mGlu4 receptor selectivity. |
| Biological Activity | PHCCC 是一种选择性的 mGluR4 异位增效剂，具有抗帕金森病作用。[1] |
| IC50 | Group ImGluR receptors: 3μM(IC50)[1] |
| Data Literature Source | [1]. Marino MJ，et al. Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13668-73. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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