| CAS |
104632-25-9 |
| Chinese Name |
盐酸普拉克索 |
| English Name |
Pramipexole Dihydrochloride |
| Synonyms |
盐酸普拉克索;(S)-普拉克索二盐酸化物;(S)-PramipexoleDihydrochloride; |
| Molecular Formula |
C10H19Cl2N3S |
| Molecular Weight |
284.25 |
| Solubility |
Soluble in Water(Need ultrasonic) |
| Purity |
≥98% |
| Appearance |
White to off-white Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL |
MFCD00876894 |
| SMILES |
CCCN[C@H]1CCC2=C(C1)SC(=N2)N.Cl.Cl |
| InChIKey |
QMNWXHSYPXQFSK-KLXURFKVSA-N |
| InChI |
InChI=1S/C10H17N3S.2ClH/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7，12H，2-6H2，1H3，(H2，11，13);2*1H/t7-;;/m0../s1 |
| PubChem CID |
119569 |
| Target Point |
Dopamine Receptor |
| Passage |
Neuronal Signaling;GPCR & G Protein |
| Background |
It is a selective dopamine D2-type receptor agonist with blood-brain barrier (BBB) permeability that is used in studies related to Parkinsons and leg hyperactivity syndrome. |
| Biological Activity |
Pramipexole Dihydrochloride 是一种具有选择性和血脑屏障（BBB）穿透性的多巴胺 D2 型受体激动剂，可用于帕金森病（PD）和不宁腿综合征（RLS）的研究。[1-4] |
| In Vitro |
Pramipexole Dihydrochloride dhydrochloride hydrate is in part transported across the BBB by an organic cation-sensitive transporter. The Pramipexole Dihydrochloride transport in RBEC1 was pH-dependent，but sodium- and membrane potential-independent.[1] Pramipexole Dihydrochloride dhydrochloride hydrate(0.01-10 μM; 72 hours; hiPSCs)produced dose-dependent increases of dendritic arborization and soma size.[2] Pramipexole Dihydrochloride dhydrochloride hydrate reduced levodopa-induced THir cell loss in a dose-dependent and saturable fashion(ED50 = 500 pM).[3] |
| In Vivo |
Pramipexole Dihydrochloride dhydrochloride hydrate(0.25 mg and 1 mg/kg body weight)induces the neurological recovery through mitochondrial pathways in ischemia/reperfusion injury.[4] |
| Animal Experiment |
Male Wistar rats underwent transient middle cerebral artery occlusion(tMCAO)and then received Pramipexole Dihydrochloride(0.25 mg and 1 mg/kg body weight)at 1，6，12 and 18 h post-occlusion.[4] |
| Data Literature Source |
[1]. Okura T，et al. Blood-brain barrier transport of pramipexole，a dopamine D2 agonist. Life Sci. 2007 Apr 3;80(17):1564-71.
[2]. Collo G，et al. Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling. Neural Plast. 2018 Feb 4;2018:4196961.
[3]. Carvey PM，et al. Attenuation of levodopa-induced toxicity in mesencephalic cultures by pramipexole. J Neural Transm (Vienna). 1997;104(2-3):209-28.
[4]. Andrabi SS，er al. Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke. Dis Model Mech. 2019 Aug 29;12(8):dmm033860. |
| Unit |
Bottle |
| Specification |
25mg |
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