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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Pramipexole DihydrochlorideCAS：104632-25-9
Molecular Formula：C10H19Cl2N3S
Molecular Weight：284.25
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 104632-25-9 |
| Name | Pramipexole Dihydrochloride |
| Molecular Formula | C10H19Cl2N3S |
| Molecular Weight | 284.25 |
| Solubility | Soluble in Water(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00876894 |
| SMILES | CCCN[C@H]1CCC2=C(C1)SC(=N2)N.Cl.Cl |
| InChIKey | QMNWXHSYPXQFSK-KLXURFKVSA-N |
| InChI | InChI=1S/C10H17N3S.2ClH/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7，12H，2-6H2，1H3，(H2，11，13);2*1H/t7-;;/m0../s1 |
| PubChem CID | 119569 |
| Target Point | Dopamine Receptor |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist， with Kis of 2.2 nM， 3.9 nM， 0.5 nM and 1.3 nM for D2-type receptor， D2， D3 and D4 receptors， respectively. Pramipexole dihydrochloride can be used for the research of Parkinsons disease (PD) and restless legs syndrome (RLS)[1-3]. |
| Biological Activity | Pramipexole Dihydrochloride 是一种具有选择性和血脑屏障（BBB）穿透性的多巴胺 D2 型受体激动剂，可用于帕金森病（PD）和不宁腿综合征（RLS）的研究。[1-4] |
| Data Literature Source | [1]. Okura T，et al. Blood-brain barrier transport of pramipexole，a dopamine D2 agonist. Life Sci. 2007 Apr 3;80(17):1564-71. [2]. Collo G，et al. Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling. Neural Plast. 2018 Feb 4;2018:4196961. [3]. Carvey PM，et al. Attenuation of levodopa-induced toxicity in mesencephalic cultures by pramipexole. J Neural Transm (Vienna). 1997;104(2-3):209-28. [4]. Andrabi SS，er al. Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke. Dis Model Mech. 2019 Aug 29;12(8):dmm033860. |
| Unit | Bottle |
| Specification | 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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