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5-(N,N-Hexamethylene)-amiloride

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Cat.No：IH1670 Solarbio

CAS：1428-95-1

Molecular Formula：C₁₂H₁₈ClN₇O

Molecular Weight：311.77

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	1428-95-1
Name	5-(N,N-Hexamethylene)-amiloride
Molecular Formula	C₁₂H₁₈ClN₇O
Molecular Weight	311.77
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
SMILES	C1CCCN(CC1)C2=NC(=C(N=C2Cl)C(=O)N=C(N)N)N
InChIKey	RQQJJXVETXFINY-UHFFFAOYSA-N
InChI	InChI=1S/C12H18ClN7O/c13-8-10(20-5-3-1-2-4-6-20)18-9(14)7(17-8)11(21)19-12(15)16/h1-6H2，(H2，14，18)(H4，15，16，19，21)
PubChem CID	1794
Target Point	Na+/H+ exchanger;HIV
Passage	Membrane Transporter&Ion Channel
Background	It is an effective Na+/H+ exchange inhibitor and also an ion channel inhibitor of HIV-1 Vpu virus.
Biological Activity	5-(N，N-Hexamethylene)-amiloride 是一种 Na+/H+ 交换抑制剂，一种 HIV-1 Vpu 病毒离子通道的抑制剂，可抑制小鼠肝炎病毒 (MHV) 复制和人冠状病毒 229E (HCoV229E) 在培养的 L929 细胞中的复制，其 EC50 分别为 3.91 μM 和 1.34 μM。[1-2]
Data Literature Source	[1]. Rich IN，et al. Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na(+)/H(+) exchanger. Blood. 2000 Feb 15;95(4):1427-34. [2]. Wilson L，et al. Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication. Virology. 2006 Sep 30;353(2):294-306.
Unit	Bottle
Specification	5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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