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My CartReactivity：Mouse
Application：FCM
Clone Type：Monoclonal Antibody
Storage：Store at 2-8℃. Avoid exposure to light.
Gene ID：21936
Host：Rat
Qty：
Size：
| Name | Anti-CD357(APC) Monoclonal Antibody |
| Host | Rat |
| Clone Type | Monoclonal Antibody |
| Subtype | IgG2b |
| Dilution Ratio | FCM 10^6cells加0.06ug |
| Target | CD357 |
| Background | Glucocorticoid-induced TNFR-related protein (GITR), also known as CD357 or TNFRSF18, is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is expressed constitutively at high levels in T regulatory cells (Treg cells) and plays a key role in dominant immunological self-tolerance maintained by CD25+CD4+ regulatory T cells (PMID: 11812990). It is expressed at low levels on resting responder T cells. The expression of GITR on T cells can be upregulated upon activation (PMID: 15770698). GITR is activated by GITR ligand (GITRL) which is mainly expressed on APC. GITR-GITRL interactions could co-stimulate both responder T-cell functions and the suppressive functions of Treg cells (PMID: 16868552). |
| Swiss Prot | O35714 |
| Gene ID | 21936 |
| Subcellular Location | Cell membrane Secreted |
| Immunogen | Mouse CD25+ CD4+ T cells |
| Calculated MW | 24kDa |
| Purification Method | Affinity purification |
| Storage Buffer | Phosphate based buffer with 0.09% sodium azide and 0.1% gelatin，pH 7.2. |
| Storage | Store at 2-8℃. Avoid exposure to light. |
| Unit | Piece |
| Y-Dilution Ratio | FCM 10^6cells+0.06ug. |
| Specification | 25ug 100ug |
| Reactivity | Mouse |
| Application | FCM |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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