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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > BMS-5CAS：1338247-35-0
Molecular Formula：C17H14Cl2F2N4OS
Molecular Weight：431.29
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 1338247-35-0 |
| Name | BMS-5 |
| Molecular Formula | C17H14Cl2F2N4OS |
| Molecular Weight | 431.29 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD17019327 |
| SMILES | CC(C)C(=O)NC1=NC=C(S1)C2=CC(=NN2C3=C(C=CC=C3Cl)Cl)C(F)F |
| InChIKey | IVUGBSGLHRJSSP-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H14Cl2F2N4OS/c1-8(2)16(26)23-17-22-7-13(27-17)12-6-11(15(20)21)24-25(12)14-9(18)4-3-5-10(14)19/h3-8，15H，1-2H3，(H，22，23，26) |
| PubChem CID | 56965901 |
| Target Point | LIM Kinase (LIMK) |
| Passage | Cytoskeleton |
| Background | BMS-5 is a highly effective LIMK inhibitor, which inhibits LIMK1 and LIMK2. |
| Biological Activity | BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2， respectively.[1-3] |
| Data Literature Source | [1]. Ross-Macdonald P， et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol Cancer Ther. 2008 Nov;7(11):3490-8. [2]. Petrilli A， et al. LIM Domain Kinases as Potential Therapeutic Targets for Neurofibromatosis Type 2.Oncogene. Oncogene. 2014 Jul 3;33(27):3571-82. [3]. Lunardi P， et al. Effects of Hippocampal LIMK Inhibition on Memory Acquisition， Consolidation， Retrieval， Reconsolidation， and Extinction. Mol Neurobiol. 2017 Jan 13. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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