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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > BMS-214662CAS：195987-41-8
Molecular Formula：C25H23N5O2S2
Molecular Weight：489.61
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
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| CAS | 195987-41-8 |
| Name | BMS-214662 |
| Molecular Formula | C25H23N5O2S2 |
| Molecular Weight | 489.61 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | C1C(N(CC2=C(N1CC3=CN=CN3)C=CC(=C2)C#N)S(=O)(=O)C4=CC=CS4)CC5=CC=CC=C5 |
| InChIKey | OLCWFLWEHWLBTO-HSZRJFAPSA-N |
| InChI | InChI=1S/C25H23N5O2S2/c26-13-20-8-9-24-21(11-20)15-30(34(31，32)25-7-4-10-33-25)23(12-19-5-2-1-3-6-19)17-29(24)16-22-14-27-18-28-22/h1-11，14，18，23H，12，15-17H2，(H，27，28)/t23-/m1/s1 |
| PubChem CID | 448545 |
| Target Point | Farnesyl Transferase |
| Passage | Metabolic Enzyme&Protease |
| Background | BMS-214662 is an effective and selective farnesyl transfer inhibitor with anti-tumor activity. |
| Biological Activity | BMS-214662 is a potent and selective farnesyl transferase inhibitor with potent antitumor activity with an IC50 of 1.35 nM.[1-2] |
| IC50 | IC50: 1.35 nM (farnesyl transferase)， 1.3 μM (Ras-CVLL)， 2.3 μM (K-Ras)[1] |
| Data Literature Source | [1]. Hunt JT， et al. Discovery of (R)-7-cyano-2，3，4， 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1，4-benzodiazepine (BMS-214662)， a farnesyltransferase inhibitor with potent preclinical antitumor activity. J Med Chem. 200 [2]. Rose WC， et al. Preclinical antitumor activity of BMS-214662， a highly apoptotic and novel farnesyltransferase inhibitor. Cancer Res. 2001 Oct 15;61(20):7507-17. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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