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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > BMS-816336CAS：1009583-20-3
Molecular Formula：C21H27NO3
Molecular Weight：341.44
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1009583-20-3 |
| Name | BMS-816336 |
| Molecular Formula | C21H27NO3 |
| Molecular Weight | 341.44 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | C1C2CC3CC(C2O)CC1C3(CC(=O)N4CC(C4)O)C5=CC=CC=C5 |
| InChIKey | OAAZMUGLOXGVNH-UHFFFAOYSA-N |
| InChI | InChI=1S/C21H27NO3/c23-18-11-22(12-18)19(24)10-21(15-4-2-1-3-5-15)16-6-13-7-17(21)9-14(8-16)20(13)25/h1-5，13-14，16-18，20，23，25H，6-12H2 |
| PubChem CID | 59336911 |
| Target Point | 11β-HSD |
| Passage | Metabolic Enzyme&Protease |
| Background | BMS-816336 is a potent inhibitor of 11β-hydroxy steroid dehydrogenase type 1 (11β-HSD1). |
| Biological Activity | BMS-816336 is a novel， potent and orally bioavailable inhibitor against human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with an IC50 of 3.0 nM[1]. |
| IC50 | IC50: 3.0nM(11β-HSD1)[1] |
| Data Literature Source | [1]. Ye XY，et al. Discovery of Clinical Candidate 2-((2S，6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336]，an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor. J Med Chem. 2017 Jun 22;60(12):4932-4948. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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