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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > NSC 305787CAS：785718-37-8
Molecular Formula：C25H30Cl2N2O
Molecular Weight：445.42
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 785718-37-8 |
| Name | NSC 305787 |
| Molecular Formula | C25H30Cl2N2O |
| Molecular Weight | 445.42 |
| Solubility | Soluble in DMSO(Need ultrasonic or Water bath) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | C1CCNC(C1)C(C2=CC(=NC3=C2C=C(C=C3Cl)Cl)C45CC6CC(C4)CC(C6)C5)O |
| InChIKey | YNGQUUFYBFKLNH-UHFFFAOYSA-N |
| InChI | InChI=1S/C25H30Cl2N2O/c26-17-8-18-19(24(30)21-3-1-2-4-28-21)10-22(29-23(18)20(27)9-17)25-11-14-5-15(12-25)7-16(6-14)13-25/h8-10，14-16，21，24，28，30H，1-7，11-13H2 |
| PubChem CID | 470998 |
| Target Point | Ezrin |
| Passage | Others |
| Background | NSC305787 is an ezrin inhibitor that inhibits PKC Ι The resulting phosphorylation of ezrin has anti-tumor activity. |
| Biological Activity | NSC305787 is an inhibitor of ezrin with a Kd of 5.85 μM， inhibits the phosphorylation of ezrin caused by PKCΙ with an IC50 of 8.3 μM， has antitumor activity.[1-2] |
| IC50 | Kd: 5.85 μM (ezrin)[1].IC50: 8.3 μM (ezrin)[1] |
| Data Literature Source | [1]. Bulut G，et al. Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells. Oncogene. 2012 Jan 19;31(3):269-81. [2]. elik H，et al. Ezrin Inhibition Up-regulates Stress Response Gene Expression. J Biol Chem. 2016 Jun 17;291(25):13257-70. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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