{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > GardiquimodCAS：1020412-43-4
Molecular Formula：C17H23N5O
Molecular Weight：313.4
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
Size：
| CAS | 1020412-43-4 |
| Name | Gardiquimod |
| Molecular Formula | C17H23N5O |
| Molecular Weight | 313.4 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N |
| InChIKey | FHJATBIERQTCTN-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H23N5O/c1-4-19-9-13-21-14-15(22(13)10-17(2，3)23)11-7-5-6-8-12(11)20-16(14)18/h5-8，19，23H，4，9-10H2，1-3H3，(H2，18，20) |
| PubChem CID | 44592366 |
| Target Point | Toll-like Receptor (TLR7/8) |
| Passage | Immunology & Inflammation |
| Background | Gardiquimod is a TLR7/8 agonist. |
| Biological Activity | Gardiquimod，an imidazoquinoline analog，is a TLR7/8 agonist. Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod specifically activates TLR7 when used at concentrations below 10 μM[1-2]. |
| Data Literature Source | [1]. Buitendijk M，et al. Gardiquimod: a Toll-like receptor-7 agonist that inhibits HIV type 1 infection of human macrophages and activated T cells. AIDS Res Hum Retroviruses. 2013 Jun;29(6):907-18. [2]. Zhou Z，et al. TLR7/8 agonists promote NK-DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma. Cancer Lett. 2015 Dec 28;369(2):298-306. |
| Unit | Bottle |
| Specification | 2mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
