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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > Microcystin-LRCAS：101043-37-2
Molecular Formula：C49H74N10O12
Molecular Weight：995.17
Storage：Powder:-20℃，1 year;In solvent(Mother Liquid):-20℃，1 month;-80℃，6 months
Purity：HPLC≥95%
Appearance：Solid
Qty：
Size：
| CAS | 101043-37-2 |
| Name | Microcystin-LR |
| Molecular Formula | C49H74N10O12 |
| Molecular Weight | 995.17 |
| Solubility | Soluble in Ethanol/DMSO |
| Purity | HPLC≥95% |
| Appearance | Solid |
| Storage | Powder:-20℃，1 year;In solvent(Mother Liquid):-20℃，1 month;-80℃，6 months |
| SMILES | C[C@H]1[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(=C)N(C(=O)CC[C@@H](NC1=O)C(=O)O)C)C)CC(C)C)C(=O)O)C)CCCN=C(N)N)/C=C/C(=C/[C@H](C)[C@H](CC2=CC=CC=C2)OC)/C |
| InChIKey | ZYZCGGRZINLQBL-GWRQVWKTSA-N |
| InChI | InChI=1S/C49H74N10O12/c1-26(2)23-37-46(66)58-40(48(69)70)30(6)42(62)55-35(17-14-22-52-49(50)51)45(65)54-34(19-18-27(3)24-28(4)38(71-10)25-33-15-12-11-13-16-33)29(5)41(61)56-36(47(67)68)20-21-39(60)59(9)32(8)44(64)53-31(7)43(63)57-37/h11-13，15-16，18-19，24，26，28-31，34-38，40H，8，14，17，20-23，25H2，1-7，9-10H3，(H，53，64)(H，54，65)(H，55，62)(H，56，61)(H，57，63)(H，58，66)(H，67，68)(H，69，70)(H4，50，51，52)/b19-18+，27-24+/t28-，29-，30-，31+，34-，35-，36+，37-，38-，40+/m0/s1 |
| PubChem CID | 445434 |
| Target Point | Phosphatase(PP1/2A) |
| Passage | Metabolic Enzyme/Protease |
| Background | Microcystin-LR is an effective inhibitor of protein phosphatase type 1 and 2A (PP1/2A). |
| Biological Activity | Microcystin-LR is a potent inhibitor of type 1 and type 2A protein phosphatases (PP1 and PP2A)， with IC50s of 1.7 nM and 0.04 nM， respectively.[1-2] |
| IC50 | IC50: 1.7nM(PP1);0.04nM(PP2A)[1]. |
| Data Literature Source | [1]. Honkanen RE，et al. Characterization of microcystin-LR，a potent inhibitor of type 1 and type 2A protein phosphatases. J Biol Chem. 1990 Nov 15;265(32):19401-4. [2]. Lone Y，et al. Microcystin-LR Induced Immunotoxicity in Mammals. J Toxicol. 2016:8048125. |
| Unit | Bottle |
| Specification | 100ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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