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2-Aminoimidazole

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Cat.No：IA5770 Solarbio

CAS：7720-39-0

Molecular Formula：C₃H₅N₃

Molecular Weight：83.09

Storage：Store at -20℃，2 years

Purity：≥98%

Appearance：Liquid

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Product Information

CAS	7720-39-0
Name	2-Aminoimidazole
Molecular Formula	C₃H₅N₃
Molecular Weight	83.09
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Liquid
Storage	Store at -20℃，2 years
Density	1.313 g/ml
MDL	MFCD00792530
SMILES	C1=CN=C(N1)N
InChIKey	DEPDDPLQZYCHOH-UHFFFAOYSA-N
InChI	InChI=1S/C3H5N3/c4-3-5-1-2-6-3/h1-2H，(H3，4，5，6)
PubChem CID	82140
Target Point	Others
Passage	Others
Background	2-Aminoimidazole is an effective antibiofilm compound, which can damage the self-protection ability of bacteria by inhibiting the formation of biofilm, and can be used as an antibacterial adjuvant in related studies.
Biological Activity	2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of human arginase I with a Ki of 3.6 mM[1][2][3].
IC50	bacteria[1].Ki: 3.6 mM (human arginase I)[3]
Data Literature Source	[1]. Thompson RJ，et，al. Identification of BfmR，a response regulator involved in biofilm development，as a target for a 2-Aminoimidazole-based antibiofilm agent. Biochemistry. 2012 Dec 11;51(49):9776-8. [2]. Jacobs L，et，al. 2-Aminoimidazoles as potent inhibitors of contaminating brewery biofilms. Biofouling. 2021 Feb 11;1-17. [3]. Ilies M，et，al. 2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I. J Med Chem. 2010 May 27;53(10):4266-76.
Unit	Bottle
Specification	100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.

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