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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > HSP990CAS：934343-74-5
Molecular Formula：C20H18FN5O2
Molecular Weight：379.39
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 934343-74-5 |
| Name | HSP990 |
| Molecular Formula | C20H18FN5O2 |
| Molecular Weight | 379.39 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22628859 |
| SMILES | CC1=C2C(=NC(=N1)N)CC(NC2=O)C3=C(C=C(C=C3)F)C4=NC(=CC=C4)OC |
| InChIKey | WSMQUUGTQYPVPD-OAHLLOKOSA-N |
| InChI | InChI=1S/C20H18FN5O2/c1-10-18-16(26-20(22)23-10)9-15(25-19(18)27)12-7-6-11(21)8-13(12)14-4-3-5-17(24-14)28-2/h3-8，15H，9H2，1-2H3，(H，25，27)(H2，22，23，26)/t15-/m1/s1 |
| PubChem CID | 46216556 |
| Target Point | Hsp90 |
| Passage | Cell Cycle;Metabolic Enzyme&Protease |
| Background | It is a potent and selective Hsp90 inhibitor. |
| Biological Activity | NVP-HSP990 is a potent， selective and orally active Hsp90 inhibitor， with IC50 values of 0.6， 0.8， and 8.5 nM for Hsp90α， Hsp90β， and Grp94， respectively.[1-3] |
| Data Literature Source | [1]. Menezes DL， et al. The novel oral Hsp90 inhibitor NVP-HSP990 exhibits potent and broad-spectrum antitumor activities in vitro and in vivo. Mol Cancer Ther. 2012 Mar;11(3):730-9. [2]. McBride CM， et al. Design， structure-activity relationship， and in vivo characterization of the development candidate NVP-HSP990. J Med Chem. 2014 Nov 13;57(21):9124-9. [3]. Lamottke B， et al. The novel， orally bioavailable HSP90 inhibitor NVP-HSP990 induces cell cycle arrest and apoptosis in multiple myeloma cells and acts synergistically with melphalan by increased cleavage of caspases. Eur J Haematol. 2012 May;88(5):406-15. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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