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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > IcotinibCAS：610798-31-7
Molecular Formula：C22H21N3O4
Molecular Weight：391.42
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
Size：
| CAS | 610798-31-7 |
| Name | Icotinib |
| Molecular Formula | C22H21N3O4 |
| Molecular Weight | 391.42 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22124501 |
| SMILES | C#CC1=CC(=CC=C1)NC2=NC=NC3=CC4=C(C=C32)OCCOCCOCCO4 |
| InChIKey | QQLKULDARVNMAL-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H21N3O4/c1-2-16-4-3-5-17(12-16)25-22-18-13-20-21(14-19(18)23-15-24-22)29-11-9-27-7-6-26-8-10-28-20/h1，3-5，12-15H，6-11H2，(H，23，24，25) |
| PubChem CID | 22024915 |
| Target Point | EGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK |
| Background | It is an effective and selective EGFR inhibitor. |
| Biological Activity | Icotinib (BPI-2009) is a potent and specific EGFR inhibitor with an IC50 of 5 nM; also inhibits mutant EGFRL858R， EGFRL858R/T790M， EGFRT790M and EGFRL861Q. Icotinib is a click chemistry reagent， it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.[1] |
| Data Literature Source | [1]. Tan F， et al. Icotinib (BPI-2009H)， a novel EGFR tyrosine kinase inhibitor， displays potent efficacy in preclinical studies. Lung Cancer. 2012 May;76(2):177-82. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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