Torin 1
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Cat.No：IT3880 Solarbio
CAS：1222998-36-8
Molecular Formula：C35H28F3N5O2
Molecular Weight：607.62
Storage：Powder:2-8℃，2 years
Purity：≥98%
Appearance：Solid
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
GPCR & G Protein
Neuronal Signal Pathway
MAPK
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TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
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Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
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> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > Torin 1
Product Information
| CAS | 1222998-36-8 |
| Name | Torin 1 |
| Molecular Formula | C35H28F3N5O2 |
| Molecular Weight | 607.62 |
| Solubility | Soluble in DMSO ≥0.1mg/mL(Need ultrasonic or Water bath) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years |
| MDL | MFCD18782653 |
| SMILES | CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F |
| InChIKey | AKCRNFFTGXBONI-UHFFFAOYSA-N |
| InChI | InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36，37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12，17-21H，2，13-16H2，1H3 |
| PubChem CID | 49836027 |
| Target Point | mTOR |
| Passage | PI3K/Akt/mTOR |
| Background | Torin 1 is a potent mTOR inhibitor that inhibits the mTORC1/2 complex. |
| Biological Activity | Torin 1 is a potent inhibitor of mTOR with an IC50 of 3 nM. Torin 1 inhibits both mTORC1/2 complexes with IC50 values between 2 and 10 nM. Torin 1 is an effective inducer of autophagy.[1-4] |
| Data Literature Source | [1]. Thoreen CC， et al， An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem， 2009， 284(12)， 8023-8032. [2]. Liu Q， et al. Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1，6]naphthyridin-2(1H)-one as a highly potent， selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. J Med Che [3]. Bi C， et al. Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas. Haematologica. 2017 Apr;102(4):755-764. [4]. Brandt M， et al. mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis. Cell Metab. 2018 Jan 9;27(1):118-135.e8. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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