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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > BAY 60-2770CAS：1027642-43-8
Molecular Formula：C35H33F4NO5
Molecular Weight：623.63
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
Size：
| CAS | 1027642-43-8 |
| Name | BAY 60-2770 |
| Molecular Formula | C35H33F4NO5 |
| Molecular Weight | 623.63 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | C1=CC(=CC=C1CN(CCCCC(=O)O)CCC2=C(C=CC(=C2)F)OCC3=CC=C(C=C3)C4=CC=C(C=C4)C(F)(F)F)C(=O)O |
| InChIKey | CRQMDXFUKDWARU-UHFFFAOYSA-N |
| InChI | InChI=1S/C35H33F4NO5/c36-31-16-17-32(45-23-25-6-8-26(9-7-25)27-12-14-30(15-13-27)35(37，38)39)29(21-31)18-20-40(19-2-1-3-33(41)42)22-24-4-10-28(11-5-24)34(43)44/h4-17，21H，1-3，18-20，22-23H2，(H，41，42)(H，43，44) |
| PubChem CID | 23546312 |
| Target Point | Guanylate Cyclase |
| Passage | Metabolic Enzyme&Protease |
| Background | BAY 60-2770 is an effective and selective activator of guanosine cyclase (sGC). BAY 60-2770 increases the activity of sGC in a nitric oxide independent manner. BAY 60-2770 has anti-fibrosis activity. |
| Biological Activity | BAY 60-2770 is a potent， selective， and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect[1-2]. |
| Data Literature Source | [1]. Knorr A，et al. Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis. Arzneimittelforschung. 2008;58(2):71-80. [2]. Leiria LO，et al. The soluble guanylyl cyclase activator BAY 60-2770 ameliorates overactive bladder in obese mice. J Urol. 2014 Feb;191(2):539-47. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
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