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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > (S)-(-)-Bay-K-8644CAS：98625-26-4
Molecular Formula：C16H15F3N2O4
Molecular Weight：356.3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 98625-26-4 |
| Name | (S)-(-)-Bay-K-8644 |
| Molecular Formula | C16H15F3N2O4 |
| Molecular Weight | 356.3 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00153769 |
| SMILES | CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC |
| InChIKey | ZFLWDHHVRRZMEI-ZDUSSCGKSA-N |
| InChI | InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17，18)19/h4-7，13，20H，1-3H3/t13-/m0/s1 |
| PubChem CID | 6603728 |
| Target Point | Calcium Channel |
| Passage | Membrane Transporter&Ion Channel;Neuronal Signaling |
| Background | (S) - (-) - Bay-K-8644 is an L-type calcium channel agonist. |
| Biological Activity | (S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. (S)-(-)-Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM).[1-3] |
| IC50 | EC50: 32nM(IBa)[1] |
| Data Literature Source | [1]. Zhu HL，et al. Antagonistic actions of S(-)-Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba(2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):609-15. [2]. Mironov SL，et al. L-type Ca2+ channels in inspiratory neurones of mice and their modulation by hypoxia. J Physiol. 1998 Oct 1;512 ( Pt 1):75-87. [3]. Rampe D，et al. Functional interactions between two Ca2+ channel activators，(S)-Bay K 8644 and FPL 64176，in smooth muscle. Mol Pharmacol. 1992 Apr;41(4):599-602. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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