{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > CEP-28122 mesylate saltCAS：1022958-60-6(free base)
Molecular Formula：C29H39ClN6O6S
Molecular Weight：635.17
Storage：Powder:2-8℃，2 years
Purity：≥98%
Appearance：Solid
Qty：
Size：
| CAS | 1022958-60-6(free base) |
| Name | CEP-28122 mesylate salt |
| Molecular Formula | C29H39ClN6O6S |
| Molecular Weight | 635.17 |
| Solubility | Soluble in DMSO ≥0.1mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years |
| SMILES | COC1=C(C=CC2=C1CCC(CC2)N3CCOCC3)NC4=NC=C(C(=N4)NC5C6CC(C5C(=O)N)C=C6)Cl.CS(=O)(=O)O |
| InChIKey | PIIIZYXUYVVFSN-WWQCAQLDSA-N |
| InChI | InChI=1S/C28H35ClN6O3.CH4O3S/c1-37-25-20-8-7-19(35-10-12-38-13-11-35)6-4-16(20)5-9-22(25)32-28-31-15-21(29)27(34-28)33-24-18-3-2-17(14-18)23(24)26(30)36;1-5(2，3)4/h2-3，5，9，15，17-19，23-24H，4，6-8，10-14H2，1H3，(H2，30，36)(H2，31，32，33，34);1H3，(H，2，3，4)/t17-，18+，19+，23+，24-;/m1./s1 |
| PubChem CID | 91885507 |
| Target Point | ALK |
| Passage | Protein Tyrosine Kinase/RTK;Angiogenesis |
| Background | CEP-28122 mesylate salt is a highly effective selective ALK inhibitor. |
| Biological Activity | CEP-28122 mesylate salt， a diaminopyrimidine derivative， is a potent， selective， and orally bioavailable ALK inhibitor， with an IC50 value of 1.9 nM for recombinant ALK kinase activity. CEP-28122 has antitumor activity in experimental models of ALK-positive human cancers. CEP-28122 mesylate salt has good pharmacodynamic and pharmacokinetic activity[1]. |
| Data Literature Source | [1]. Mangeng Cheng，et al. CEP-28122，a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers. Mol Cancer Ther. 2012 Mar;11(3):670-9. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
