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Determination of Significance：
Angiotensin Converting Enzyme (ACE, EC 3.4.15.1, also called ACE1) is a zinc-containing peptidyl dipeptide hydrolase with a calculated molecular mass of 120-150 kDa. ACE is widely detected in the endothelial cell of organ tissues included lung, brain, kidney. ACE catalyzes the formation of angiotensin I to angiotensin II, which could cause vasoconstriction, promote synthesis and release of adrenocortical hormone aldosterone. It is important to detect ACE activity for diagnosis and treatment of lung, liver, thyroid and other organ diseases.
Measurement Principle：
ACE could catalyze FAPGG to form FAP and glycylglycine. FAPGG has a characteristic absorption peak at 340 nm, and ACE activity is calculated by measuring the rate of decrease in absorbance at 340nm.
Self Provided：
Spectrophotometer, desk centrifuge, balance, transferpettor, 1mL quartz cuvette, constant temperature foster box/water-bath, mortar/homogenizer/cell ultrasonic crusher, ice and distilled water.
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