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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Scopolamine hydrobromideCAS：114-49-8
Molecular Formula：C17H22BrNO4
Molecular Weight：384.26
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 114-49-8 |
| Name | Scopolamine hydrobromide |
| Molecular Formula | C17H22BrNO4 |
| Molecular Weight | 384.26 |
| Solubility | Soluble in Water/DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 204-050-6 |
| MDL | MFCD00012647 |
| SMILES | CN1[C@@H]2CC(C[C@H]1[C@H]3[C@@H]2O3)OC(=O)[C@H](CO)C4=CC=CC=C4.Br |
| InChIKey | WTGQALLALWYDJH-WYHSTMEOSA-N |
| InChI | InChI=1S/C17H21NO4.BrH/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;/h2-6，11-16，19H，7-9H2，1H3;1H/t11?，12-，13-，14+，15-，16+;/m1./s1 |
| PubChem CID | 6603108 |
| Target Point | mAChR |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | Scopolamine hydrobromide is a high affinity (nM) muscarinic antagonist. 5-HT3 receptor-responses are reversibly inhibited by Scopolamine with an IC50 of 2.09 μM.[1-3] |
| Data Literature Source | Saturation binding (8 point) curves are measured by incubating either crude extracts of HEK 293 cells stably expressing 5-HT3 receptors， or Guinea pig membrane preparations， in 0.5 mL incubations containing 10 mM HEPES buffer (pH 7.4) and 0.1-1 nM [3H]granisetron or 1-10 nM [3H]N-methylScopolamine. Competition binding (10 point) is determined by incubating the same receptors preparations in 0.5 mL HEPES buffer containing either 0.6 nM [3H]granisetron or 0.6 nM [3H]N-methylScopolamine， and differing concentrations of competing ligands. Non-specific binding is determined with 1 mM quipazine or 10 μM Scopolamine respectively. Incubations are terminated by filtration onto Whatman GF/B filters wetted with HEPES buffer+0.3% polyethyleneimine， followed by two rapid washes with ice-cold HEPES buffer. Protein concentration is calculated using a Lowry protein assay with bovine serum albumin standards. Radioactivity is measured using a Tri-Carb 2100 TR scintillation counter[1]. |
| Unit | Bottle |
| Specification | 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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