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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > PF-06751979CAS：1818339-66-0
Molecular Formula：C18H19F2N5O3S2
Molecular Weight：455.5
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
Size：
| CAS | 1818339-66-0 |
| Name | PF-06751979 |
| Molecular Formula | C18H19F2N5O3S2 |
| Molecular Weight | 455.5 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CC1CC2CSC(=NC2(CO1)C3=NC(=CS3)NC(=O)C4=NC=C(C=C4)OC(F)F)N |
| InChIKey | ZLZUHACSRMOLLV-RAALSFIWSA-N |
| InChI | InChI=1S/C18H19F2N5O3S2/c1-9-4-10-6-30-17(21)25-18(10，8-27-9)15-24-13(7-29-15)23-14(26)12-3-2-11(5-22-12)28-16(19)20/h2-3，5，7，9-10，16H，4，6，8H2，1H3，(H2，21，25)(H，23，26)/t9-，10-，18-/m0/s1 |
| PubChem CID | 118435360 |
| Target Point | Beta-secretase (BACE1) |
| Passage | Neuronal Signaling |
| Background | PF-06751979 is a potent， brain permeable β-amyloid precursor protein lyase 1 (BACE1) inhibitor. |
| Biological Activity | PF-06751979 is a potent， brain penetrant， β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay.[1] |
| IC50 | IC50: 7.3 nM (BACE1)， 194 nM (BACE2)[1] |
| Data Literature Source | [1]. ONeill BT， et al. Design and Synthesis of Clinical Candidate PF-06751979: A Potent， Brain Penetrant， β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation. J Med Chem. 2018 May 24;61(10):4476-4504. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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