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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Acotiamide monohydrochloride trihydrateCAS：773092-05-0
Molecular Formula：C21H37ClN4O8S
Molecular Weight：541.06
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 773092-05-0 |
| Name | Acotiamide monohydrochloride trihydrate |
| Molecular Formula | C21H37ClN4O8S |
| Molecular Weight | 541.06 |
| Solubility | Soluble in DMSO ≥10mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD28101055 |
| SMILES | CC(C)N(CCNC(=O)C1=CSC(=N1)NC(=O)C2=CC(=C(C=C2O)OC)OC)C(C)C.O.O.O.Cl |
| InChIKey | NPTDXIXCQCFGKC-UHFFFAOYSA-N |
| InChI | InChI=1S/C21H30N4O5S.ClH.3H2O/c1-12(2)25(13(3)4)8-7-22-20(28)15-11-31-21(23-15)24-19(27)14-9-17(29-5)18(30-6)10-16(14)26;;;;/h9-13，26H，7-8H2，1-6H3，(H，22，28)(H，23，24，27);1H;3*1H2 |
| PubChem CID | 6918406 |
| Target Point | AChE |
| Passage | Neuronal Signaling |
| Background | It is a selective AChE inhibitor. |
| Biological Activity | Acotiamide monohydrochloride trihydrate is an orally active， selective and reversible acetylcholinesterase (AChE) inhibitor， with IC50 of 1.79 μM. Acotiamide monohydrochloride trihydrate can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide monohydrochloride trihydrate has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory [1][2][3]. |
| IC50 | AChE |
| Data Literature Source | [1]. Hiroshi Yamawaki，et al. Acotiamide attenuates central urocortin 2-induced intestinal inflammatory responses，and urocortin 2 treatment reduces TNF-α productions in LPS-stimulated macrophage cell lines. Neurogastroenterol Motil. 2020 Aug;32(8):e13813. [2]. Matsunaga Y，et al. Acotiamide hydrochloride (Z-338)，a new selective acetylcholinesterase inhibitor，enhances gastric motility without prolonging QT interval in dogs: comparison with cisapride，itopride，and mosapride. J Pharmacol Exp Ther. 2011 Mar;336(3):791-800. [3]. Kazuyoshi Y oshii，et al. Physiologically-Based Pharmacokinetic and Pharmacodynamic Modeling for the Inhibition of Acetylcholinesterase by Acotiamide，A Novel Gastroprokinetic Agent for the Treatment of Functional Dyspepsia，in Rat Stomach. Pharmaceutical Research，33(2)，292–300. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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