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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > AM580CAS：102121-60-8
Molecular Formula：C22H25NO3
Molecular Weight：351.44
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 102121-60-8 |
| Name | AM580 |
| Molecular Formula | C22H25NO3 |
| Molecular Weight | 351.44 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00673916 |
| SMILES | CC1(CCC(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)(C)C)C |
| InChIKey | SZWKGOZKRMMLAJ-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H25NO3/c1-21(2)11-12-22(3，4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10，13H，11-12H2，1-4H3，(H，23，24)(H，25，26) |
| PubChem CID | 2126 |
| Target Point | RARα |
| Passage | Metabolic Enzyme&Protease |
| Background | AM580 is a selective RARα agonist with IC50 and EC50 of 8 nM and 0.36 nM， respectively.[1-3] |
| Data Literature Source | Approximately 1×106 NB4， HL-60， and APL fresh leukemic cells or CML neutrophils are harvested， pelletted by centrifugation at 400 g for 10 minutes， washed once with 0.9% NaCl， and centrifuged again. The washed cell pellet is resuspended in homogenization buffer (1 mM MgCl2， 1 mM CaCl2， 20 mM ZnCl2， 0.1 mM NaCl， 0.1% [vol/vol] Triton X-100， 50 mM Tris/HCl， pH 7.4) and disrupted by vigorous pipetting. The homogenate is used for the LAP assay， which is performed with p-nitrophenol phosphate as substrate according to the instructions of the manufacturer. LAP activity is normalized for the content of protein in the sample. Proteins are measured according to the Bradford method using BSA fraction V as a standard. One unit of LAP activity is defined as the amount of enzyme capable of transforming 1 nmol of substrate in 1 minute at 25°C. Enzyme assays are performed in conditions of linearity relative to the substrate and to the concentration of proteins.[1] |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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