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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > AST 487CAS：630124-46-8
Molecular Formula：C26H30F3N7O2
Molecular Weight：529.56
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 630124-46-8 |
| Name | AST 487 |
| Molecular Formula | C26H30F3N7O2 |
| Molecular Weight | 529.56 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD11983171 |
| SMILES | CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)NC3=CC=C(C=C3)OC4=NC=NC(=C4)NC)C(F)(F)F |
| InChIKey | ODPGGGTTYSGTGO-UHFFFAOYSA-N |
| InChI | InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27，28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9，14-15，17H，3，10-13，16H2，1-2H3，(H，30，31，32)(H2，33，34，37) |
| PubChem CID | 11409972 |
| Target Point | RET |
| Passage | Protein Tyrosine Kinase/RTK;Apoptosis |
| Background | AST 487 is a RET kinase inhibitor that inhibits RET autophosphorylation and downstream effector activation. |
| Biological Activity | AST 487 is a RET kinase inhibitor with IC50 of 880 nM， inhibits RET autophosphorylation and activation of downstream effectors， also inhibits Flt-3 with IC50 of 520 nM.[1] |
| IC50 | IC50: 880 nM (RET)， 170 nM (KDR)， 790 nM (Flt-4)， 500 nM (c-Kit)， 520 nM (Flt-3)， 20 nM (Abl)[1] |
| Data Literature Source | [1]. Akeno-Stuart N， et al. The RET Kinase Inhibitor NVP-AST487 Blocks Growth and Calcitonin Gene Expression through Distinct Mechanisms in Medullary Thyroid Cancer Cells. Cancer Res. 2007 Jul 15;67(14):6956-64. [2]. Weisberg E， et al. Antileukemic effects of the novel， mutant FLT3 inhibitor NVP-AST487: effects on PKC412-sensitive and -resistant FLT3-expressing cells. Blood. 2008 Dec 15;112(13):5161-70. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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