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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > AV-412 free baseCAS：451492-95-8
Molecular Formula：C27H28ClFN6O
Molecular Weight：507
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 451492-95-8 |
| Name | AV-412 free base |
| Molecular Formula | C27H28ClFN6O |
| Molecular Weight | 507 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD16038939 |
| SMILES | CC(C)(C#CC1=CC2=C(C=C1NC(=O)C=C)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)N4CCN(CC4)C |
| InChIKey | ZAJXXUDARPGGOC-UHFFFAOYSA-N |
| InChI | InChI=1S/C27H28ClFN6O/c1-5-25(36)33-23-16-20-24(30-17-31-26(20)32-19-6-7-22(29)21(28)15-19)14-18(23)8-9-27(2，3)35-12-10-34(4)11-13-35/h5-7，14-17H，1，10-13H2，2-4H3，(H，33，36)(H，30，31，32) |
| PubChem CID | 9806229 |
| Target Point | EGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK |
| Background | AV-412 free base is an EGFR inhibitor. |
| Biological Activity | AV-412 free base (MP-412 free base) is an EGFR inhibitor with IC50s of 0.75， 0.5， 0.79， 2.3， 19 nM for EGFR， EGFRL858R， EGFRT790M， EGFRL858R/T790M and ErbB2， respectively.[1] |
| Data Literature Source | [1]. Suzuki T， et al. Pharmacological characterization of MP-412 (AV-412)， a dual epidermal growth factor receptorand ErbB2 tyrosine kinase inhibitor. Cancer Sci. 2007 Dec;98(12):1977-84. |
| Unit | Bottle |
| Specification | 2mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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