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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > TGF-β/Smad > BMP signaling agonist sb4CAS：100874-08-6
Molecular Formula：C14H10BrNOS
Molecular Weight：320.2
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to light brown Solid
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| CAS | 100874-08-6 |
| Name | BMP signaling agonist sb4 |
| Molecular Formula | C14H10BrNOS |
| Molecular Weight | 320.2 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to light brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD01603921 |
| SMILES | C1=CC=C2C(=C1)N=C(O2)SCC3=CC=C(C=C3)Br |
| InChIKey | JDVOIBFEFVKUPL-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H10BrNOS/c15-11-7-5-10(6-8-11)9-18-14-16-12-3-1-2-4-13(12)17-14/h1-8H，9H2 |
| PubChem CID | 731364 |
| Target Point | BMP4 |
| Passage | TGF-beta/Smad |
| Background | BMP signaling agonist sb4 is a potent bone morphogenetic protein 4 (BMP4) signaling agonist that activates BMP signaling by stabilizing intracellular P-mad -1/5/9. BMP signaling agonist sb4 also activates BMP4 target genes in typical BMP signaling pathways. |
| Biological Activity | BMP signaling agonist sb4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC50 value of 74 nM， activates BMP signaling by stabilizing intracellular p-SMAD-1/5/9. BMP signaling agonist sb4 activates BMP4 target genes (inhibitors of DNA binding， Id1 and Id3) canonical BMP signaling[1]. |
| Data Literature Source | [1]. Bradford STJ，et al. High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds.J Biol Chem. 2019 Mar 1;294(9):3125-3136. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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