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My CartReactivity：Human,Mouse
Application：WB
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：7443
Host：Rabbit
Qty：
Size：
| Name | Anti-VRK1 Polyclonal Antibody |
| Host | Rabbit |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Predicted Reactivity | Bovine;Zebrafish |
| Dilution Ratio | WB 1:1000-3000. |
| Target | VRK1 |
| Background | This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells， such as those in testis， thymus， fetal liver， and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and， in vitro， to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene， therefore， may regulate cell proliferation. This protein also phosphorylates histone， casein， and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. |
| Swiss Prot | Q99986 |
| Gene ID | 7443 |
| Subcellular Location | Nucleus |
| Immunogen | Recombinant protein of human VRK1 |
| Public Immunogen Range | 1-350aa |
| Calculated MW | 45kDa |
| Observed MW | 50kDa |
| Purification Method | Octanoic acid-ammonium sulfate precipitation |
| Storage Buffer | PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Unit | Piece |
| Specification | 20ul 50ul 100ul |
| Reactivity | Human Mouse |
| Application | WB |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Western blot analysis with VRK1 antibody diluted at 1:2000;Lane: HeLa,MCF7,A549.
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