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My CartReactivity：Mouse,Human,Rat
Application：WB
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：10891
Host：Rabbit
Qty：
Size：
| Name | Anti-PGC1 alpha/beta Polyclonal Antibody |
| Host | Rabbit |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Dilution Ratio | WB 1:500-1000. |
| Target | PGC1 alpha/beta |
| Background | PGC-1αis a transcriptional coactivator that regulates the genes involved in energy metabolism. It is the master regulator of mitochondrial biogenesis. This protein interacts with the nuclear receptor PPAR-γ， which permits the interaction of this protein with multiple transcription factors. This protein can interact with， and regulate the activities of， cAMP response element-binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis， and is a major factor causing slow-twitch rather than fast-twitch muscle fiber types. Endurance exercise has been shown to activate the PGC-1α gene in human skeletal muscle. Exercise-induced PGC-1αin skeletal muscle increases autophagy and unfolded protein response. PGC-1α protein may be also involved in controlling blood pressure， regulating cellular cholesterol homoeostasis， and the development of obesity. |
| Swiss Prot | Q9UBK2 |
| Gene ID | 10891 |
| Subcellular Location | Nucleus |
| Immunogen | A synthetic peptide of Human PGC1α/β |
| Calculated MW | 91kDa |
| Observed MW | 91kDa |
| Purification Method | Affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide，100 μg/ml BSA and 50% glycerol. |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Unit | Piece |
| Specification | 100ul |
| Reactivity | Rat Mouse Human |
| Application | WB |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Western blot analysis with PGC1 alpha/beta antibody diluted at 1:500;Lane: 293T U-2OS Mouse liver Mouse kidney Rat liver Rat kidney.
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