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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > PP121CAS：1092788-83-4
Molecular Formula：C17H17N7
Molecular Weight：319.36
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1092788-83-4 |
| Name | PP121 |
| Molecular Formula | C17H17N7 |
| Molecular Weight | 319.36 |
| Solubility | Soluble in DMSO ≥2mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD12912434 |
| SMILES | C1CCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CN=C5C(=C4)C=CN5)N |
| InChIKey | NVRXTLZYXZNATH-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H17N7/c18-15-13-14(11-7-10-5-6-19-16(10)20-8-11)23-24(12-3-1-2-4-12)17(13)22-9-21-15/h5-9，12H，1-4H2，(H，19，20)(H2，18，21，22) |
| PubChem CID | 24905142 |
| Target Point | mTOR;DNK-PK;VEGFR2;Src;PDGFR |
| Passage | PI3K/Akt/mTOR;DNA Damage/DNA Repair;Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | PP121 is a multi target kinase inhibitor that inhibits mTOR， DNK-PK， VEGFR2， Src， and PDGFR. |
| Biological Activity | PP121 is a multi-targeted kinase inhibitor with IC50s of 10， 60， 12， 14， 2 nM for mTOR， DNK-PK， VEGFR2， Src， PDGFR， respectively.[1-2] |
| Data Literature Source | [1]. Apsel B， et al. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol， 2008， 4(11)， 691-699. [2]. Peng Y， et al. The anti-esophageal cancer cell activity by a novel tyrosine/phosphoinositide kinase inhibitor PP121. Biochem Biophys Res Commun. 2015 Sep 11;465(1):137-44. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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