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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Sodium SalicylateCAS：54-21-7
Molecular Formula：C7H5NaO3
Molecular Weight：160.1
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 54-21-7 |
| Name | Sodium Salicylate |
| Molecular Formula | C7H5NaO3 |
| Molecular Weight | 160.1 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-198-0 |
| MDL | MFCD00002440 |
| SMILES | C1=CC=C(C(=C1)C(=O)[O-])O.[Na+] |
| InChIKey | ABBQHOQBGMUPJH-UHFFFAOYSA-M |
| InChI | InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4，8H，(H，9，10);/q;+1/p-1 |
| PubChem CID | 16760658 |
| Target Point | COX;S6K;NF-κB |
| Passage | Immunology & Inflammation;MAPK;NF-κB |
| Background | Sodium Salicylate is an S6K inhibitor that inhibits COX-2 activity. Sodium Salicylate is also an inhibitor of NF-κB. |
| Biological Activity | Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation. Sodium Salicylate is also a S6K inhibitor.Sodium Salicylate is a NF-κB inhibitor that decreases inflammatory gene expression and improves repair in aged muscle.[1-4] |
| Data Literature Source | [1]. Mitchell JA， et al. Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor kappaB) activation: role of arachidonic acid. Mol Pharmacol. 1997 Jun;51(6):907-12. [2]. Dongmei Bai， et al. Palmitic acid negatively regulates tumor suppressor PTEN through T366 phosphorylation and protein degradation. Cancer Lett. 2020 Oct 8;S0304-3835(20)30506-1. [3]. Nixon M， et al. Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans， mediating insulin sensitization. Diabetes. 2012 Apr;61(4):790-6. [4]. Juhyun Oh， et al. Age-associated NF-κB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function. Aging (Albany NY). 2016 Nov; 8(11): 2871–2884. |
| Unit | Bottle |
| Specification | 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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