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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > Roflumilast N-oxideCAS：292135-78-5
Molecular Formula：C17H14Cl2F2N2O4
Molecular Weight：419.21
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 292135-78-5 |
| Name | Roflumilast N-oxide |
| Molecular Formula | C17H14Cl2F2N2O4 |
| Molecular Weight | 419.21 |
| Solubility | Soluble in DMSO ≥10mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | C1CC1COC2=C(C=CC(=C2)C(=O)N=C3C(=CN(C=C3Cl)O)Cl)OC(F)F |
| InChIKey | KHXXMSARUQULRI-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H14Cl2F2N2O4/c18-11-6-23(25)7-12(19)15(11)22-16(24)10-3-4-13(27-17(20)21)14(5-10)26-8-9-1-2-9/h3-7，9，17，25H，1-2，8H2 |
| PubChem CID | 9940999 |
| Target Point | Phosphodiesterase (PDE) |
| Passage | Metabolic Enzyme&Protease |
| Background | It is a PDE type 4 inhibitor. |
| Biological Activity | Roflumilast N-oxide is a PDE type 4 inhibitor.[1-3] |
| Data Literature Source | [1]. Victoni T， et al. Roflumilast n-oxide associated with PGE2 prevents the neutrophil elastase-induced production of chemokines by epithelial cells. Int Immunopharmacol. 2016 Jan;30:1-8. [2]. Milara J，et al. Simvastatin Increases the Ability of Roflumilast N-oxide to Inhibit Cigarette Smoke-Induced Epithelial to Mesenchymal Transition in Well-differentiated Human Bronchial Epithelial Cells in vitro. COPD. 2015 Jun;12(3):320-31. [3]. Vollert S， et al. The glucose-lowering effects of the PDE4 inhibitors roflumilast and roflumilast-N-oxide in db/db mice. Diabetologia. 2012 Oct;55(10):2779-2788. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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