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My CartReactivity：Rat,Human,Mouse
Application：IHC
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：595
Host：Rabbit
Qty：
Size：
| Name | Anti-CCND1 Polyclonal Antibody |
| Host | Rabbit |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Predicted Reactivity | Dog;Cow;Chimpanzee;Chicken |
| Dilution Ratio | IHC 1:50-200. |
| Target | CCND1 |
| Background | The protein encoded by this gene belongs to the highly conserved cyclin family，whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6，whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations，amplification and overexpression of this gene，which alters cell cycle progression，are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq，Jul 2008] |
| Swiss Prot | P24385 |
| Gene ID | 595 |
| Subcellular Location | Cytoplasm Nucleus |
| Immunogen | A synthetic peptide of human CCND1 |
| Public Immunogen Range | 1-51/295aa |
| Calculated MW | 34kDa |
| Observed MW | 31kDa |
| Purification Method | Affinity purification |
| Storage Buffer | PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Unit | bottle |
| Specification | 20ul 50ul 100ul |
| Reactivity | Human Mouse Rat |
| Application | IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Immunohistochemistry of paraffin-embedded Human renal cancer with CCND1 antibody diluted at 1:100.
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