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My CartStorage：Store at -20℃，2 years.Avoid freeze/thaw cycles.
Appearance：Lyophilized powder
Gene ID：1238
Application：Blocking Peptide of K108561P Antibody
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| Name | ACKR2 Antibody Blocking Peptide |
| Appearance | Lyophilized powder |
| Storage | Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| Swiss Prot | O00590 |
| Gene ID | 1238 |
| Background | Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades， resulting instead in chemokine sequestration， degradation， or transcytosis. Also known as interceptor or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2， CCL3， CCL3L1， CCL4， CCL5， CCL7， CCL8， CCL11， CCL13， CCL17， CCL22， CCL23， CCL24， SCYA2/MCP-1， SCY3/MIP-1-alpha， SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation， activates a beta-arrestin 1 (ARRB1)-dependent， G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane， increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues， on the surfaces of lymphatic vessels， and in placenta， plays an essential role in the resolution of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs. |
| Application | Blocking Peptide of K108561P Antibody |
| Source | Synthetic |
| Purification Method | HPLC |
| Biological Activity | Not tested |
| Unit | Piece |
| Specification | 500ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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