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My CartStorage：Store at -20℃，2 years.Avoid freeze/thaw cycles.
Appearance：Lyophilized powder
Gene ID：9833
Application：Blocking Peptide of K113481P Antibody
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| Name | MELK Antibody Blocking Peptide |
| Appearance | Lyophilized powder |
| Storage | Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| Swiss Prot | Q14680 |
| Gene ID | 9833 |
| Interval Range | 335-385/651aa |
| Background | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation， self-renewal of stem cells， apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14， CDC25B， MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle， notably by mediating phosphorylation of CDC25B， promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14， possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622， thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. |
| Application | Blocking Peptide of K113481P Antibody |
| Source | Synthetic |
| Purification Method | HPLC |
| Biological Activity | Not tested |
| Unit | Piece |
| Specification | 500ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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