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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > Pazopanib Hydrochloride(10mM in DMSO,Sterile）CAS：635702-64-6
Molecular Formula：C21H23N7O2S·HCl
Molecular Weight：473.98
Storage：Stroe at -20℃，6 months.
Appearance：Sterile solution
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| CAS | 635702-64-6 |
| Name | Pazopanib Hydrochloride(10mM in DMSO,Sterile） |
| Molecular Formula | C21H23N7O2S·HCl |
| Molecular Weight | 473.98 |
| Solubility | Please use according to your own experimental requirements. |
| Appearance | Sterile solution |
| Storage | Stroe at -20℃，6 months. |
| Target Point | c-FMS/CSF-1R;c-Kit;FGFR;PDGFR;VEGFR |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | Pazopanib is a multi-target inhibitor. |
| Biological Activity | Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1， VEGFR2， VEGFR3， PDGFRβ， c-Kit， FGFR1， and c-Fms with an IC50 of 10， 30， 47， 84， 74， 140 and 146 nM， respectively.[1-2] |
| Data Literature Source | [1]. Harris PA， et al. Discovery of 5-[[4-[(2，3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib)， a novel and potent vascular endothelial growth factor receptor inhibitor. J Med Chem. 2008， 51(15)， 4632-4640. [2]. Thakur A， et al. Pazopanib， a multitargeted tyrosine kinase inhibitor， reduces diabetic retinal vascular leukostasis and leakage. Microvasc Res. 2011 Nov;82(3):346-50. |
| Unit | bottle |
| Specification | 1ml |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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