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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > Ellagic acid(10mM in DMSO,Sterile）CAS：476-66-4
Molecular Formula：C14H6O8
Molecular Weight：302.19
Storage：Stroe at -20℃，6 months.
Appearance：Sterile solution
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| CAS | 476-66-4 |
| Name | Ellagic acid(10mM in DMSO,Sterile） |
| Molecular Formula | C14H6O8 |
| Molecular Weight | 302.19 |
| Solubility | Please use according to your own experimental requirements. |
| Appearance | Sterile solution |
| Storage | Stroe at -20℃，6 months. |
| Target Point | Casein Kinase（CK） |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Stem Cells |
| Background | Ellagic acid is an antioxidant and a potent， ATP-competitive inhibitor of CK2. |
| Biological Activity | Ellagic acid is a natural antioxidant， and acts as a potent and ATP-competitive inhibitor of CK2 and SHP2， with an IC50 of 40 nM and a Ki of 20 nM.[1-4] |
| Data Literature Source | [1]. Cozza G， et al. Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application. J Med Chem. 2006 Apr 20;49(8):2363-6. [2]. Rizk HA， et al. Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin-induced neurotoxicity in rats. J Biochem Mol Toxicol. 2017 Dec;31(12). [3]. Ahire V， et al. Ellagic Acid Enhances Apoptotic Sensitivity of Breast Cancer Cells to γ-Radiation. Nutr Cancer. 2017 Aug-Sep;69(6):904-910. [4]. Ma CH， et al. Discovery of ellagic acid as a competitive inhibitor of Src homology phosphotyrosyl phosphatase 2 (SHP2) for cancer treatment: In vitro and in silico study. Int J Biol Macromol. 2023 Nov 5;254(Pt 2):127845. |
| Unit | bottle |
| Specification | 1ml |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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