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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > IC261(10mM in DMSO,Sterile）CAS：186611-52-9
Molecular Formula：C18H17NO4
Molecular Weight：311.33
Storage：Stroe at -20℃，6 months.
Appearance：Sterile solution
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| CAS | 186611-52-9 |
| Name | IC261(10mM in DMSO,Sterile） |
| Molecular Formula | C18H17NO4 |
| Molecular Weight | 311.33 |
| Solubility | Please use according to your own experimental requirements. |
| Appearance | Sterile solution |
| Storage | Stroe at -20℃，6 months. |
| Target Point | Casein Kinase（CK） |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Stem Cells |
| Background | Ibuprofen is a COX-1 and COX-2 inhibitor with anti-inflammatory activity. |
| Biological Activity | IC261 is a selective， ATP-competitive CK1 inhibitor， with IC50s of 1 μM， 1 μM， 16 μM for Ckiδ， Ckiε and Ckiα1， respectively.[1-3] |
| Data Literature Source | [1]. Mashhoon N， et al. Crystal structure of a conformation-selective casein kinase-1 inhibitor. J Biol Chem. 2000 Jun 30;275(26):20052-60. [2]. St?ter M， et al. Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells. Oncogene. 2005 Dec 1;24(54):7964-75. [3]. Brockschmidt C， et al. Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo. Gut. 2008 Jun;57(6):799-806. |
| Unit | bottle |
| Specification | 1ml |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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