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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > Celastrol(10mM in DMSO,Sterile）CAS：34157-83-0
Molecular Formula：C29H38O4
Molecular Weight：450.61
Storage：Stroe at -20℃，6 months.
Appearance：Sterile solution
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| CAS | 34157-83-0 |
| Name | Celastrol(10mM in DMSO,Sterile） |
| Molecular Formula | C29H38O4 |
| Molecular Weight | 450.61 |
| Solubility | Please use according to your own experimental requirements. |
| Appearance | Sterile solution |
| Storage | Stroe at -20℃，6 months. |
| Target Point | Proteasome |
| Passage | Metabolic Enzyme&Protease |
| Background | Celastrol is a proteasome inhibitor that potently and preferentially inhibits the chymotrypsin-like activity of the 20S proteasome. |
| Biological Activity | Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM.[1-2] |
| Data Literature Source | [1]. Yang H， et al. Celastrol， a triterpene extracted from the Chinese "Thunder of God Vine，" is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 2006 May 1;66(9):4758-65 [2]. Guan Y， et al. Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1α-SIRT3 signaling pathway. Int J Mol Med. 2016 May;37(5):1229-38. |
| Unit | bottle |
| Specification | 1ml |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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