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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > GW3965 Hydrochloride(10mM in DMSO,Sterile）CAS：405911-17-3
Molecular Formula：C33H31ClF3NO3·HCl
Molecular Weight：618.51
Storage：Stroe at -20℃，6 months.
Appearance：Sterile solution
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| CAS | 405911-17-3 |
| Name | GW3965 Hydrochloride(10mM in DMSO,Sterile） |
| Molecular Formula | C33H31ClF3NO3·HCl |
| Molecular Weight | 618.51 |
| Solubility | Please use according to your own experimental requirements. |
| Appearance | Sterile solution |
| Storage | Stroe at -20℃，6 months. |
| Target Point | Liver X Receptor（LXR） |
| Passage | Metabolic Enzyme&Protease |
| Background | GW3965 HCl is a potent and selective LXR agonist. |
| Biological Activity | GW3965 hydrochloride is a potent and selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ， respectively.[1-4] |
| IC50 | EC50: 190 nM (hLXRα)， 30 nM (hLXRβ)[4] |
| Data Literature Source | [1]. Mitro， Nico.， et al. LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals. Neurochemistry International (2012)， 60(6)， 616-621. [2]. Guo， Deliang.， et al. An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway. Cancer Discovery (2011)， 1(5)， 442-456. [3]. Spyridon， Michael.， et al. LXR as a novel antithrombotic target. Blood (2011)， 117(21)， 5751-5761. [4]. Collins JL， et al. Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem. 2002 May 9;45(10):1963-6. |
| Unit | bottle |
| Specification | 1ml |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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