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My CartReactivity：Human,Mouse,Rat
Application：WB,IHC
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：1139/89832
Purity：CHRNA7
Qty：
Size：
| Name | Anti-CHRNA7 Polyclonal Antibody |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Dilution Ratio | WB 1:3000-5000.IHC 1:25-100. |
| Target | Rabbit |
| Background | The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains， a variable cytoplasmic loop， a fourth conserved transmembrane domain， and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel， displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by， and highly sensitive to， alpha-bungarotoxin. Once this receptor binds acetylcholine， it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. |
| Swiss Prot | P36544 |
| Gene ID | 1139/89832 |
| Subcellular Location | Cell membrane Secreted |
| Immunogen | A synthetic peptide of human CHRNA7 |
| Public Immunogen Range | 180-230/502aa |
| Calculated MW | 11/56/59KDa |
| Observed MW | Chimpanzee;Monkey |
| Purification Method | Affinity purification |
| Storage Buffer | PBS with 50% Glycerol， 0.03% Proclin300， 0.5% BSA， pH 7.3. |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Purity | CHRNA7 |
| Conjugation Concentration | bottle |
| Conjugation | 48KDa |
| Specification | 50ul 100ul |
| Reactivity | Human Mouse Rat |
| Application | WB IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
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