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My CartReactivity：Mouse,Rat
Application：ELISA,WB,IF,IHC
Clone Type：Polyclonal Antibody
Storage：Store at -20℃.Avoid freeze/thaw cycles.
Gene ID：177
Purity：RAGE
Qty：
Size：
| Name | Anti-RAGE Polyclonal Antibody |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Dilution Ratio | WB 1:500-2000.IHC 1:100-500.IF 1:100-500.ELISA 1:5000-10000 |
| Target | Rabbit |
| Background | Advanced glycosylation end product-specific receptor (AGER;RAGE) is a member of the immunoglobulin superfamily of cell surface molecules that binds molecules that have been irreversibly modified by non-enzymatic glycation and oxidation and are know as advanced glycation end products (AGEs).It is expressed by endothelium mononuclear phagocytes neurons and smooth muscle cells.Whereas RAGE is present at high levels during development especially in the central nervous system its levels decline during maturity.The increased expression of RAGE is associated with several pathological states such as diabetic vasculopathy neuropathy retinopathy and other disorders including Alzheimer’s disease and immune/inflammatory reactions of the vessel walls.In diabetic tissues the production of RAGE is due to the overproduction of AGEs that eventually overwhelm the protective properties of RAGE.This results in oxidative stress and endothelial cell dysfunction that leads to vascular disease in diabetics.In the brain RAGE also binds amyloid beta (Ab).Because Ab is overproduced in neurons and vessels in the brains of Alzheimer disease this leads to the hyperstimulation of RAGE.The RAGE-Ab interaction is thought to result in oxidative stress leading to neuronal degeneration. |
| Swiss Prot | Q15109 |
| Gene ID | 177 |
| Subcellular Location | Cell membrane Single-pass type I membrane proteinSecreted |
| Immunogen | A synthetic peptide of human RAGE |
| Public Immunogen Range | 41-150/404aa |
| Calculated MW | 13/35/36/37/38/39/41/43/45kDa |
| Observed MW | Human;Pig;Cow;Dog |
| Purification Method | Affinity purification |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA，0.03% Proclin300 and 50% Glycerol. |
| Storage | Store at -20℃.Avoid freeze/thaw cycles. |
| Purity | RAGE |
| Conjugation Concentration | bottle |
| Conjugation | 58/50kDa |
| Specification | 50ul 100ul |
| Reactivity | Mouse Rat |
| Application | WB IHC IF ELISA |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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