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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > AEBSFCAS：30827-99-7
Molecular Formula：C8H11ClFNO2S
Molecular Weight：239.69
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 30827-99-7 |
| Name | AEBSF |
| Molecular Formula | C8H11ClFNO2S |
| Molecular Weight | 239.69 |
| Solubility | Soluble in Water ≥50mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINCES 608-547-2 |
| MDL | MFCD00132962 |
| SMILES | O=S(C1=CC=C(CCN)C=C1)(F)=O.[H]Cl |
| InChIKey | WRDABNWSWOHGMS-UHFFFAOYSA-N |
| InChI | InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H |
| PubChem CID | 186136 |
| Target Point | Serine Protease |
| Passage | Metabolic Enzyme&Protease |
| Background | AEBSF is an irreversible inhibitor of serine proteases, inhibiting, for example, chymotrypsin, kallikrein, plasmin, thrombin and trypsin. |
| Biological Activity | AEBSF是丝氨酸蛋白酶的不可逆抑制剂，可抑制例如胰凝乳蛋白酶，激肽释放酶，纤溶酶，凝血酶和胰蛋白酶。[1-4] |
| Data Literature Source | [1]. Citron M， et al. Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF. Neuron. 1996 Jul; 17 (1) :171-9 [2]. Nakabo Y， et al. Lysis of leukemic cells by human macrophages: inhibition by 4- (2-aminoethyl) -benzenesulfonyl fluoride (AEBSF) ， a serine protease inhibitor. J Leukoc Biol. 1996 Sep; 60 (3) :328-36. [3]. Buitrago-Rey R， et al. Evaluation of two inhibitors of invasion: LY311727 [3- (3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy) propane phosphonic acid] and AEBSF [4- (2-aminoethyl) -benzenesulphonyl fluoride] in acute murine toxoplasmosis. J Antimicrob Chemother. [4]. Jiang YH， et al. Serine protease inhibitor 4- (2-aminoethyl) benzenesulfonyl fluoride hydrochloride (AEBSF) inhibits the rat embryo implantation in vivo and interferes with cell adhesion in vitro. Contraception. 2011 Dec; 84 (6) :642-8 |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in Water |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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CoCl 2 increases the expression of hypoxic markers HIF-1α, VEGF and CXCR4 in breast cancer MCF-7 cells
Click to check >>Author：Li Q , Ma R , Zhang M .
IF：2.7850
Publish_to：Oncol Lett.
PMID：29391899
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