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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > AgomelatineCAS：138112-76-2
Molecular Formula：C15H17NO2
Molecular Weight：243.3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 138112-76-2 |
| Name | Agomelatine |
| Molecular Formula | C15H17NO2 |
| Molecular Weight | 243.3 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 629-727-7 |
| MDL | MFCD00916659 |
| SMILES | CC(NCCC1=C2C=C(OC)C=CC2=CC=C1)=O |
| InChIKey | YJYPHIXNFHFHND-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H17NO2/c1-11(17)16-9-8-13-5-3-4-12-6-7-14(18-2)10-15(12)13/h3-7,10H,8-9H2,1-2H3,(H,16,17) |
| PubChem CID | 82148 |
| Target Point | Melatonin Receptor; 5-HT Receptor |
| Passage | GPCR/G Protein; Neuronal Signaling |
| Background | Agomelatine is a specific agonist for the MT1 and MT2 receptors. Agomelatine is also a selective 5-HT2C receptor antagonist. |
| Biological Activity | Agomelatine (S20098; AGO-178; S-20098; AGO178; Valdoxan, Melitor, Thymanax) is a potent and specific agonist of MT1 and MT2 receptors with anti-depressive activity. It activates the isoforms of MT receptors such as CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2 with Kis of 0.1, 0.06, 0.12, and 0.27 nM, respectively. It is a unique antidepressant and is developed for treatment of major depressive disorder (MDD). It shows low affinities to cloned human 5-HT2A and 5-HT1A. In the in vivo studies, agomelatine causes increase of dopamine and noradrenaline levels via blocking the inhibitory input of 5-HT2C.[1] |
| Data Literature Source | [1]. Behav Brain Res. 2011 Mar 17;218(1):121-8 [2]. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jul;29(6):908-16. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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