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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > Angiotensin II humanCAS：4474-91-3
Molecular Formula：C50H71N13O12
Molecular Weight：1046.18
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 4474-91-3 |
| Name | Angiotensin II human |
| Molecular Formula | C50H71N13O12 |
| Molecular Weight | 1046.18 |
| Solubility | Soluble in Water |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 2017-001-1 |
| MDL | MFCD00161484 |
| SMILES | OC1=CC=C(C[C@H](NC([C@@H](NC([C@@H](CCCNC(N)=N)NC([C@@H](N)CC(O)=O)=O)=O)C(C)C)=O)C(N[C@]([C@@H](C)CC)([H])C(N[C@@H](CC2=CN=CN2)C(N3CCC[C@@H]3C(N[C@@H](C(O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)C=C1 |
| InChIKey | CZGUSIXMZVURDU-JZXHSEFVSA-N |
| InChI | InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1 |
| PubChem CID | 172198 |
| Target Point | Angiotensin Receptor(AT) |
| Passage | GPCR & G Protein |
| Background | Angiotensin II human is a vasoconstrictor and the main bioactive peptide of the renin/angiotensin system. It is mediated mainly through the interaction between angiotensin II and G protein-coupled receptors (GPCRs)， angiotensin II type 1 receptors (AT1R)， and angiotensin II type 2 receptors (AT2R). |
| Biological Activity | Angiotensin II human是作用于 AT1 和 AT2 受体的血管收缩剂。[1-3] |
| Data Literature Source | [1]. de Gasparo M， et al. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000 Sep; 52 (3) :415-72. [2]. Fyhrquist F， et al. Role of angiotensin II in blood pressure regulation and in the pathophysiology of cardiovascular disorders. J Hum Hypertens. 1995 Nov; 9 Suppl 5:S19-24. [3]. Crowley SD， et al. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A. 2006 Nov 21; 103 (47) :17985-90. |
| Unit | Bottle |
| Specification | 1mg 5mg 10mg 10mM*1mL in Water 20mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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Lu LQ, et al. Life Sci. 2020 Jul 15;253:117700.
Lu LQ, et al. Life Sci. 2020 Jul 15;253:117700.
Deng B, et al. Journal of Receptor and Signal Transduction Research, 2020(12):1-10.
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