{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > ArbutinCAS：497-76-7
Molecular Formula：C12H16O7
Molecular Weight：272.25
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 497-76-7 |
| Name | Arbutin |
| Molecular Formula | C12H16O7 |
| Molecular Weight | 272.25 |
| Solubility | Soluble in Water/DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-850-3 |
| MDL | MFCD00016915 |
| SMILES | O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=C(O)C=C2 |
| InChIKey | BJRNKVDFDLYUGJ-RMPHRYRLSA-N |
| InChI | InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1 |
| PubChem CID | 440936 |
| Target Point | Tyrosinase |
| Passage | Metabolic Enzyme&Protease |
| Background | Arbutin is a glycoside that inhibits tyrosinase, preventing melanin production. |
| Biological Activity | Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[1-3]. |
| Data Literature Source | [1]. Garcia-Jimenez A，et al. Action of tyrosinase on alpha and beta-arbutin: A kinetic study. PLoS One. 2017 May 11;12(5):e0177330. [2]. Jiang L，et al. Investigation of the pro-apoptotic effects of arbutin and its acetylated derivative on murinemelanoma cells. Int J Mol Med. 2018 Feb;41(2):1048-1054. [3]. Nalban N，et al. Arbutin Attenuates Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting TLR-4/NF-κB Pathway in Mice. Cardiovasc Toxicol. 2019 Sep 4. |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
来源文献：Zhou N , et al . Food Funct. 2018 Sep 19;9(9):4989-4997.
来源文献：Zhou N , et al . Food Funct. 2018 Sep 19;9(9):4989-4997.
来源文献：Zhou N , et al . Food Funct. 2018 Sep 19;9(9):4989-4997.
来源文献：Zhou N , et al . Food Funct. 2018 Sep 19;9(9):4989-4997.
Sorry, there is no more information.
An integrated metabolomic strategy for the characterization of the effects of Chinese yam and its three active components on septic cardiomyopathy.
Click to check >>Author：Zhou N , Zeng MN , Li K , Yang YY , Bai ZY , Zheng
IF：4.3720
Publish_to：Food Funct.
PMID：30187904
Biotransformation of ginsenoside Rb1 and Rd to four rare ginsenosides and evaluation of their anti-melanogenic effects
Click to check >>Author：Zhang Le, Wang Liwei, Chen Yufei, Yang Yaya, Xia Guohua, Guo Yuao, Yang Huan, Shen Yuping, Meyer Anne S.
IF：3.3000
Publish_to：Journal of Natural Medicines
PMID：37329418
Manual Download
