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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > ArctigeninCAS：7770-78-7
Molecular Formula：C21H24O6
Molecular Weight：372.41
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 7770-78-7 |
| Name | Arctigenin |
| Molecular Formula | C21H24O6 |
| Molecular Weight | 372.41 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00870597 |
| SMILES | O=C1OC[C@H](CC2=CC=C(OC)C(OC)=C2)[C@H]1CC3=CC=C(O)C(OC)=C3 |
| InChIKey | NQWVSMVXKMHKTF-JKSUJKDBSA-N |
| InChI | InChI=1S/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3/t15-,16+/m0/s1 |
| PubChem CID | 64981 |
| Target Point | Others |
| Passage | Others |
| Background | Arctigenin is a lignan with potent antitumor， antioxidant， anti-inflammatory and antiviral activities. Arctigenin can be used in the study of metabolic disorders and central nervous system dysfunction. |
| Biological Activity | Arctigenin is a phytoestrogen that exerts a proliferative effect by binding to the ER. Arctigenin from Arctium lappa (L.) can both inhibit Aβ production by suppressing β-site amyloid precursor protein cleavage enzyme 1 expression and promote Aβ clearance by enhancing autophagy through AKT/mTOR signaling inhibition and AMPK/Raptor pathway activation as investigated in cells and APP/PS1 transgenic AD model mice. [2-3] |
| Data Literature Source | [1] Li QC，et al. J BUON. 2016，21(1):87-94. [2] Maxwell T，et al. Int J Oncol. 2018，52(4):1339-1349. [3] Zhu Z，et al. J Neurosci. 2013，33(32):13138-49. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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