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My CartCAS：74-79-3
Molecular Formula：C6H14N4O2
Molecular Weight：174.2
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 74-79-3 |
| Name | L-Arginine |
| Molecular Formula | C6H14N4O2 |
| Molecular Weight | 174.2 |
| Solubility | Soluble in Water ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-811-1 |
| MDL | MFCD00002635 |
| SMILES | N[C@@H](CCCNC(N)=N)C(O)=O |
| InChIKey | ODKSFYDXXFIFQN-BYPYZUCNSA-N |
| InChI | InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1 |
| PubChem CID | 6322 |
| Target Point | Others |
| Passage | Others |
| Background | L-Arginine is a NO-producing substrate of endothelial nitric oxide synthase (eNOS). L-Arginine is transported to vascular smooth muscle cells by a family of cationic amino acid transporters， where it is metabolized into nitric oxide (NO)， polyamines， or L-proline. L-Arginine is also a potent vasodilator and can be used to induce experimental acute pancreatitis. |
| Biological Activity | eNOS activity is critical for blood flow augmentation during acute L-arginine infusion, and chronic eNOS upregulation combined with L-arginine administration provides a novel strategy to elevate cerebral blood flow in the normal and ischemic brain.[1] Systemic or oral Arg administration has been shown to improve cardiovascular function and reduce myocardial ischemia in coronary artery disease patients. It reduces blood pressure and renal vascular resistance in essential hypertensive patients with normal or insufficient renal function. The main importance of Arg is attributed to its role as a precursor for the synthesis of nitric oxide (NO), a free radical molecule that is synthesized in all mammalian cells from L-Arg by NO synthase (NOS). [2] |
| Data Literature Source | [1]. Yamada M，et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17. [2]. Tapiero H，et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45. |
| Unit | Bottle |
| Specification | 10mM*1mL in Water 200mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Wang XD, Yu WL, Sun Y. Life Sci. 2021 Jul 15;277:119435.
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