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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > Atorvastatin Hemicalcium Salt TrihydrateCAS：344423-98-9
Molecular Formula：2(C33H34FN2O5)·Ca·3(H2O)
Molecular Weight：1209.4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 344423-98-9 |
| Name | Atorvastatin Hemicalcium Salt Trihydrate |
| Molecular Formula | 2(C33H34FN2O5)·Ca·3(H2O) |
| Molecular Weight | 1209.4 |
| Solubility | Soluble in DMSO ≥20mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-659-6 |
| MDL | MFCD03613598 |
| SMILES | FC1=CC=C(C2=C(C3=CC=CC=C3)C(C(NC4=CC=CC=C4)=O)=C(C(C)C)N2CC[C@@H](O)C[C@@H](O)CC([O-])=O)C=C1.[0.5Ca2+] |
| InChIKey | SHZPNDRIDUBNMH-NIJVSVLQSA-L |
| InChI | InChI=1S/2C33H35FN2O5.Ca.3H2O/c2*1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;;;;/h2*3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);;3*1H2/q;;+2;;;/p-2/t2*26-,27-;;;;/m11..../s1 |
| PubChem CID | 656846 |
| Target Point | HMG-CoA Reductase (HMGCR) |
| Passage | Metabolic Enzyme&Protease |
| Background | Atorvastatin hemicalcium salt is a potent HMG-CoA reductase inhibitor. |
| Biological Activity | Atorvastatin calcium trihydrate is a potent and selective inhibitor of HMG-CoA reductase primarily used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin is used primarily for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. As with all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body.[1] |
| Data Literature Source | [1]J Clin Invest. 1998 Jun 15;101(12):2711-9; Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H457-66. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Click to check >>Author：Jing Xia, Siyue He, Qianlong Dai, Huijie Jia, Yuchen Ge, Min Zhou, Xiaobo Wang
IF：5.6000
Publish_to：INTERNATIONAL IMMUNOPHARMACOLOGY
PMID：37336074
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