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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > 5-AzacytidineCAS：320-67-2
Molecular Formula：C8H12N4O5
Molecular Weight：244.2
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 320-67-2 |
| Name | 5-Azacytidine |
| Molecular Formula | C8H12N4O5 |
| Molecular Weight | 244.2 |
| Solubility | Soluble in Water/DMSO ≥10mg/mL;Soluble in Ethanol ≤2mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 206-280-2 |
| MDL | MFCD00006539 |
| SMILES | OC[C@H]1O[C@@H](N2C(N=C(N)N=C2)=O)[C@H](O)[C@@H]1O |
| InChIKey | NMUSYJAQQFHJEW-KVTDHHQDSA-N |
| InChI | InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1 |
| PubChem CID | 9444 |
| Target Point | Autophagy;DNA Methyltransferase |
| Passage | Autophagy;Epigenetics |
| Background | 5-Azacytidine is acytidine nucleoside analogue and a DNA methylation inhibitor that specifically inhibits DNA methylation by binding to DNA covalently trapping DNA methyltransferases. 5-Azacytidine regulates gene expression by reducing DNA methylation levels. |
| Biological Activity | 5-Azacytidine是胞苷的核苷类似物，其通过捕获 DNA甲基转移酶 特异性地抑制DNA甲基化。[1-3] |
| Data Literature Source | [1]. Christman JK. 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene. 2002 Aug 12; 21 (35) :5483-95. [2]. Creusot F， et al. Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidineand 5-aza-2'-deoxycytidine. J Biol Chem. 1982 Feb 25; 257 (4) :2041-8. [3]. Li LH，et al. Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia. Cancer Res. 1970 Nov; 30 (11) :2760-9. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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Thymoquinone Enhances Apoptosis of K562 Chronic Myeloid Leukemia Cells through Hypomethylation of SHP-1 and Inhibition of JAK/STAT Signaling Pathway
Click to check >>Author：Futoon Abedrabbu Al-Rawashde, Ola M. Al-Sanabra, Moath Alqaraleh, Ahmad Q. Jaradat, Abdullah Saleh Al-Wajeeh, Muhammad Farid Johan, Wan Rohani Wan Taib, Imilia Ismail, Hamid Ali Nagi Al-Jamal
IF：4.6000
Publish_to：Pharmaceuticals
PMID：37375831
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