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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Autophagy > Brefeldin ACAS：20350-15-6
Molecular Formula：C16H24O4
Molecular Weight：280.36
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 20350-15-6 |
| Name | Brefeldin A |
| Molecular Formula | C16H24O4 |
| Molecular Weight | 280.36 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 606-528-3 |
| MDL | MFCD00083258 |
| SMILES | O[C@@H]1C[C@]2([H])[C@@](/C=C/CCC[C@H](C)OC(/C=C/[C@H]2O)=O)([H])C1 |
| InChIKey | KQNZDYYTLMIZCT-KQPMLPITSA-N |
| InChI | InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1 |
| PubChem CID | 5287620 |
| Target Point | Autophagy; CRISPR/Cas9; Mitophagy; HSV; Antibiotic |
| Passage | Autophagy;Apoptosis; Anti-infection |
| Background | Brefeldin A is a lactone antibiotic and a specific inhibitor of protein transport. It is also an autophagy and mitophagy inhibitor. It is also a CRISPR/Cas9 agonist, which can inhibit HSV-1 virus and has anticancer activity. |
| Biological Activity | Brefeldin A是蛋白质运输 (protein trafficking) 的特异性抑制剂，其阻断蛋白质从内质网向高尔基复合体的转运。[1-5] |
| Data Literature Source | [1]. Alvarez C，et al. Brefeldin A (BFA) disrupts the organization of the microtubule and the actin cytoskeletons. Eur J Cell Biol. 1999 Jan;78(1):1-14. [2]. Colanzi A，et al. Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9794-9. [3]. Tseng CN，et al. Brefeldin A reduces anchorage-independent survival，cancer stem cell potential and migration of MDA-MB-231 human breast cancer cells. Molecules. 2014 Oct 29;19(11):17464-77. [4]. Wang J，et al. Erythroleukemia cells acquire an alternative mitophagy capability. Sci Rep. 2016 Apr 19;6:24641. [5]. Yu C，et al. Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell. 2015 Feb 5;16(2):142-7. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Notch Signaling Pathway Promotes Th17 Cell Differentiation and Participates in Thyroid Autoimmune Injury in Experimental Autoimmune Thyroiditis Mice
Click to check >>Author：Liu H. Li Y. Zhu Y. Ma L. Xue H
IF：4.0640
Publish_to：Mediators Inflamm
PMID：36643586
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