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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > BusulfanCAS：55-98-1
Molecular Formula：C6H14O6S2
Molecular Weight：246.3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 55-98-1 |
| Name | Busulfan |
| Molecular Formula | C6H14O6S2 |
| Molecular Weight | 246.3 |
| Solubility | Soluble in DMSO ≥15mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-250-2 |
| MDL | MFCD00007562 |
| SMILES | CS(=O)(OCCCCOS(C)(=O)=O)=O |
| InChIKey | COVZYZSDYWQREU-UHFFFAOYSA-N |
| InChI | InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3 |
| PubChem CID | 2478 |
| Target Point | DNA Alkylator |
| Passage | DNA Damage/DNA Repair |
| Background | Busulfan is an effective alkylator. It is a bifunctional alkylating agent of bismethyl sulfonate and is a cell cycle non-specific compound. It disrupts the structure and function of DNA by alkylating guanines in cellular DNA. |
| Biological Activity | Busulfan 是一种有效的烷化剂 (alkylator)，具有化疗作用。[1-3] |
| Data Literature Source | [1]. Probin V，et al. Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway. Free Radic Biol Med. 2007 Jun 15;42(12):1858-65. Epub 2007 Mar 31. [2]. Choi YJ，et al. Murine male germ cell apoptosis induced by busulfan treatment correlates with loss of c-kit-expression in a Fas/FasL- and p53-independent manner. FEBS Lett. 2004 Sep 24;575(1-3):41-51. [3]. Yoshida M，et al. Reduction of primordial follicles caused by maternal treatment with busulfan promotes endometrial adenocarcinoma development in donryu rats. J Reprod Dev. 2005 Dec;51(6):707-14. Epub 2005 Sep 22. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Human UC-MSC-derived exosomes facilitate ovarian renovation in rats with chemotherapy-induced premature ovarian insufficiency
Click to check >>Author：Xiaodi Pu, Leisheng Zhang, Peiyu Zhang, Yaqiong Xu, Jun Wang, Xiaomei Zhao, Zhihua Dai, Hua Zhou, Shuyun Zhao, Anran Fan
IF：5.2000
Publish_to：Frontiers in Endocrinology
PMID：37564988
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